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Date for Release of First-ever Drug that Regrows Teeth Revealed

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By Brennan Forrest - - 5 Mins Read
Girl fixing dental retainer on her teeth
Featured Photo | Diana Polekhina/Unsplash

The field of dentistry has witnessed a remarkable leap in dental care and is preparing to initiate a groundbreaking human trial for a new drug capable of regenerating lost teeth.


This marks a significant milestone as it is the first of its kind. Just under a year ago, the journey has been incredibly thrilling since the drug demonstrated its effectiveness in animals.


Now, the scientists are set to run the test on humans. If everything goes as planned, this drug that regrows new teeth could be on the market as early as 2030.


Now, what's the strategy? From September to August 2025, Kyoto University Hospital will host this groundbreaking trial of drugs to regrow new teeth.


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Health experts will host a trial involving guys aged 30 to 64 who are missing one molar or more. These participants will have the chance to regrow their missing teeth.


This intravenous test checks for the efficacy of this drug on human teeth after it was successfully done on ferrets and mice, with no notable adverse effect.


Dr. Katsu Takahashi, a highly respected dentist at Kitano Hospital, is at the forefront of transforming dental care for individuals with missing teeth. He is determined to make a difference in the lives of people, especially those dealing with tooth loss.


While acknowledging the absence of a perfect solution to this dental issue, he recognizes the strong desire for a dependable medication to regrow lost teeth. Many are pinning their hopes on such a treatment as the ultimate remedy for teeth regrowth.


So, nearly one year after the first trial, the research scientists are extending their interest to younger patients, particularly kids aged 2 to 7.


Child loses tooth
Child with a tooth in hand | Maja Marjanovic/Shutterstock


These younger patients might be missing at least four teeth due to a condition known as congenital tooth deficiency, which has affected around 1% of these young people. The team is looking to recruit individuals interested in this Phase II trial.


That's not all; there's more! These research scientists do not end there. They seem to have their eyes on another set of people: individuals dealing with partial edentulism, i.e., missing one to five permanent teeth.


This could be due to all kinds of things, like accidents or some plain old genetics. It turns out to be a common condition affecting around 5% of Americans. The good thing about this is that they're recruiting for this trial, too. 


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So, how does this dental intravenous test function? The medication targets a protein called uterine sensitization-associated gene-1 (USAG-1), which impedes tooth growth.


However, this drug inhibits its activity. By putting a stop to USAG-1's effects, it paves the way for bone morphogenetic protein (BMP) signaling, ultimately initiating the growth of new teeth, as reported in 2023.


Takahashi, a molecular biologist and scientist, has been involved in this tooth-regeneration adventure since 2005, hoping that this treatment will be a breakthrough for anyone, regardless of age.


The development of drugs to regrow teeth marks a notable advancement in dental care. Now, anyone with missing teeth can potentially regrow their teeth within just six years.